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Generic name: promethazine Brand names: Phenergan, Phenadoz, Promethegan, Romergan, Fargan, Farganesse.

Medicines class and mechanism

Phenergan is a phenothiazine in the exact same drug class as chlorpromazine (Thorazine) and trifluoperazine (Stelazine). Nonetheless, not like the other medication in this class, promethazine is not employed as an anti-psychotic. It employed as an anti-histamine, sedative, and antiemetic (anti-nausea). The entire body releases histamine throughout many kinds of allergic reactions. When histamine binds to its receptors on cells, it stimulates changes within the cells that direct to sneezing, itching, and elevated mucus creation. Antihistamines this sort of as promethazine compete with histamine for a single of the receptors for histamine (the H1 receptor) on cells. Even so, when the antihistamines bind to the receptors they do not promote the cells. As an alternative, they stop histamine from binding and stimulating the cells. Promethazine also blocks the action of acetylcholine (anticholinergic result), and this may clarify its gain in reducing the nausea of movement sickness. It is employed as a sedative due to the fact it brings about drowsiness as a aspect impact.

Phenergan prescribed for: Promethazine is recommended for dealing with nausea or vomiting, motion illness, and allergic reactions and for sedation.

Dosing of Phenergan

Allergic reactions are dealt with with 6.twenty five-25 mg three instances everyday. A simple 25 mg dose administered at bedtime also could suffice.

Nausea and vomiting might be managed with twelve.5-twenty five mg administered every single 4-6 hours as essential.

Doses of twelve.five-fifty mg at bedtime are utilised for sedation.

For avoidance of motion illness, 25 mg is employed 30 to sixty min's ahead of the movement begins and then each 8 to twelve hrs as necessary. Oral, rectal and injectable doses are similar.

Tablets may possibly be taken with or without having foodstuff.

Suppositories are unwrapped and moistened with water ahead of insertion into the rectum. If the suppository is way too delicate from becoming saved in a warm location, it could be chilled in the refrigerator for twenty to 30 min's or placed in chilly h2o just before the wrapper is taken out.

Medicines interactions

Phenergan should not be taken with any of the MAO (mono-amine oxidase) inhibitor-course of antidepressants, for case in point, isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane), simply because of the improved danger of extrapyramidal signs (EPS)--uncontrollable movements disorders.

Extreme anti-cholinergic results (described under) can arise when promethazine is employed with other antihistamines, for instance, diphenhydramine (Benadryl) some phenothiazines, for illustration, thioridazine (Mellaril) some tricyclic antidepressants, for case in point, amitriptyline (Elavil) clozapine (Clozaril), cyclobenzaprine (Flexeril), and disopyramide (Norpace).